About the lab

The Computational Biology & Gene Regulation group aims at developing cutting-edge bioinformatics tools with immediate application to real-life biological problems. Our computational biology research programme focuses on gene expression regulation and the mechanisms by which it can be disrupted in human diseases such as cancer.

Overview of cis-regulation. Figure from A. Mathelier, W. Shi, and W.W. Wasserman, Trends in Genetics, 2015.

We plan to develop new methods and tools for (1) improving the prediction of TFBSs; (2) predicting TF gene targets; (3) prioritizing cis-regulatory variants dysregulating microRNA transcriptional regulation with downstream impact on the gene regulatory programs in cancer. The mid-term goal is to combine whole genome sequencing and expression data in cancer samples to predict cis-regulatory variants dysregulating microRNA transcription and contributing to carcinogenesis.

The lab is part of the Centre for Molecular Medicine Norway (NCMM),  Nordic EMBL partner for molecular medicine, University of Oslo. Dr. Anthony Mathelier has been appointed as a group leader with a generous 5-year starting grant to launch the group.

If you would like to join our effort to analyze the regulation of gene expression and the mechanisms by which it can be disrupted in cancer, please contact Anthony at anthony.mathelier@ncmm.uio.no.


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